Despite the odds, every member of the Defenders is an omega. The Punisher is an alpha. This doesn't seem like its going to matter during the Reluctant But Necessary team-up, until ~something~ happens that triggers all the omegas into heat

++ Frank doesn't have sex with them (even though he wants to) but instead he comforts them with his scent and helps in whatever other ways he can.

+++Heavy Frank/Matt and/or Frank/Matt end game (no established relationship please)