I'm not sure about setting it in Defenders; yes, Matt would understandably be distressed, but would he really ignore Elektra? Even if she's changed, he's Matt. He can’t give up on her.

Unless maybe it's after the building collapses (he agreed to kill the Hand members, and while I think he could trick himself into not counting undead people easily enough, it could well make him think on murder). But he would have to survive somehow without being severely injured and brought to Clinton Church, so I don't know?

I liked the gang he's been involved with in the past idea.