It would also be interesting to see if this changes how Frank views Captain America. At least in the comics, he respects Cap so much, that he absolutely refuses to even fight against him; he goes berserk on anyone that disrespects Steve. I wonder if the MCU version would be the same, and if it screws with his mind a bit more?
Re: Gen or Frank/Matt; Punisher: War Zone Plot, Avengers lock Frank up, complete Isolation